From McKnight Road
- South on McKnight Rd/US-19 by turning right
- Take the I-279 South ramp towards Pittsburgh
- Merge onto I-279 S.
- Take the FT Duquesne Blvd exit on the left towards Strip District
- Keep right at the fork in the ramp
- Merge onto Fort Duquesne Blvd.
- Turn right onto 6th St.
- Turn left onto Liberty Ave.
From West Liberty Ave.
- Turn slight right onto Liberty Tunnels
- Liberty Tunnels becomes Liberty Bridge
- Stay straight onto Crosstown Blvd.
- Left onto Forbes Ave.
- Right onto 6th Ave.
- Left onto 5th Ave.
- Right onto Grant St.
- Left onto 7th Ave.
- Slight left onto Liberty Ave.
From Banksville Road
- North on Banksville Road/US-19 towards Goldstrom Ave.
- Take I-279 North ramp
- Merge onto US-19/US-22/US-30 E
- Stay straight to go onto I-279 N
- Take Blvd of Allies/Liberty Ave. exit
- Stay straight to go onto ramp
- Keep left at the fork in the ramp
- Merge onto Liberty Ave.
From Route 51
- Take Route 51 North to Liberty Tunnels
- Turn right onto Liberty Tunnels
- Liberty Tunnels becomes Liberty Bridge
- Stay straight to go onto Crosstown Blvd.
- Turn left onto Forbes Ave.
- Turn right onto 6th Ave.
- Turn left onto 5th Ave.
- Turn right onto Grant St.
- Turn left onto 7th Ave.
- Turn slight left onto Liberty Ave.
From Greentree Road
- Take I-279 North ramp towards Pittsburgh
- Merge onto US-22 E/US-30 E/I-279 N
- US-22 E/US-30 E/I-279 N becomes US-22 E/US-19/US-30 E
- Stay straight to go onto US-22 E/US-30 E/I-279 N
- Stay straight to go onto I-279 N
- Take Blvd of Allies/Liberty Ave. exit
- Stay straight to go onto ramp
- Keep left at the fork in the ramp
- Merge onto Liberty Ave.
From Route 376/Parkway East
- Take Route I-376 W towards Pittsburgh
- Take Stanwix Street exit on left
- Turn left onto Fort Pitt Blvd.
- Turn right onto Liberty Avenue